NCT02147223

Sex-dependent Effects of Flavanols on Vascular Status

Sex-dependent Effects of Flavanol Metabolism and Absorption on Vascular Status

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Heinrich-Heine University, Duesseldorf · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

Epidemiological studies suggest that certain foods rich in flavanols, including cocoa products, red wine, and tea, are associated with decreased cardiovascular mortality and morbidity. Dietary interventional studies have corroborated this finding and showed that flavanols can acutely and after sustained ingestion improve surrogate markers of cardiovascular risk including endothelial function. Endothelial dysfunction is the key event in the development and progression of cardiovascular disease. The aim of the study is to assess sex specific effects of cocoa flavanols on endothelial and vascular function in healthy subjects.

Conditions

• Cardiovascular Diseases

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Flavanol rich intervention	Flavanol intervention products (250 mg, 500 mg and 750 mg flavanols)
DIETARY_SUPPLEMENT	Flavanol free intervention	Calorically, micro- and macronutrient matched control product free of flavanols

Timeline

• Start date: 2013-11-01
• Primary completion: 2014-11-01
• Completion: 2014-11-01
• First posted: 2014-05-26
• Last updated: 2015-04-16

Locations

1 site across 1 country: Germany