NCT02146300

Effect of the Nasal Provocation on the Breathing Style

Effect of the Nasal Provocation on the Breathing Style and on the Calibration of Respiratory Effort Belts

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Oulu University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to find out how the provocation of the nose changes breathing style (specifically, frequency and tidal volume changes)

Detailed description

It is intended to clarify on both healthy and birch pollen allergic adults how the provocation of the nose with the birch pollen, dilutant and xylometazoline affect the breathing style (breathing pattern) and how these possible changes could be controlled in the measurement of the breathing with respiratory effort belts. In addition to this, our intention is to clarify the effect of the facial mask on the breathing. The allergic and control subjects undergo nasal provocation in 2 sessions. The first is done with birch pollen extract (should block the nose in allergic subjects) and the second with xylometazoline (should open the nose). The mask group undergo similar measurements without nasal exposures. The second objective of the study is to clarify if there are differences between the allergic and control subjects in the function of the autonomous nervous system during these provocations. This is done with the heart rate variability analysis method.

Conditions

• Birch Pollen Allergy
• Healthy Control Subjects

Interventions

Type	Name	Description
BIOLOGICAL	1. session birch pollen nasal exposure 2. session xylometazoline nasal exposure	Aquagen SQ 10 000 SQ/ml nasal exposure Xylometazoline 1 mg/ml nasal exposure

Timeline

• Start date: 2014-03-01
• Primary completion: 2014-06-01
• Completion: 2016-06-01
• First posted: 2014-05-23
• Last updated: 2014-05-23

Locations

1 site across 1 country: Finland