NCT02145546

Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The current evidences indicate that \~30% patients with sick sinus syndrome(SSS) would develop persistent atrial fibrillation (AF) after a long term pacing therapy. However, the accurate influence of antiarrhythmic drugs on the AF is still not well defined. The purpose of the study is to assess the therapeutic effects of various antiarrhythmic drugs (Amiodarone, Sotalol and Propafenone) on the long term management of AF in SSS patients with AF, including the reduced AF burden (duration and episodes) and persistent AF free survival rate. All patients will be followed up for 12 months.

Conditions

• Atrial Fibrillation

Interventions

Type	Name	Description
DRUG	Amiodarone	Amiodarone: 200mg three times a day for two weeks, then change to 200mg per day for the rest of the study.
DRUG	Propafenone	150mg per 8 hours, 3 times per day
DRUG	Sotalol	80mg twice per day.

Timeline

• Start date: 2014-05-01
• Primary completion: 2017-05-01
• Completion: 2017-05-01
• First posted: 2014-05-23
• Last updated: 2014-05-23

Locations

1 site across 1 country: China