NCT02145013

Portal Hypertension and Liver Resection in Patients With Hepatocellular Carcinoma

Assessment and Impact of Portal Hypertension Before and During Liver Resection in Patients With Hepatocellular Carcinoma

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Henri Mondor University Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

According to the BCLC guidelines, surgical resection of hepatocellular carcinoma complicating cirrhosis is restricted to patients with preserved liver function, single nodule without vascular invasion and with hepatic venous gradient below 10 mmHg. However, other guideline treatment, especially from eastern countries demonstrated that surgical resection is safe and feasible and provides better survival than the treatment recommended by the BCLC system for patients with similar stage. The primary goal of this study is to assess the impact of HVPG on short and long-term outcomes in HCC patients who undergo liver resection.

Detailed description

Patients with HCC and candidates for hepatectomy are classified into two groups according to the presence of portal hypertension. Short- and long-term outcomes will be compared.

Conditions

• Primary Liver Cancers

Interventions

Type	Name	Description
PROCEDURE	Liver resection	Hepatectomy by either open, laparoscopic or robotic procedures

Timeline

• Start date: 2013-11-01
• Primary completion: 2017-12-01
• Completion: 2018-05-30
• First posted: 2014-05-22
• Last updated: 2018-02-12

Locations

1 site across 1 country: France