NCT02141737

Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 272 (estimated)
• Sponsor: Tang-Du Hospital · Academic / Other
• Sex: All
• Age: 60 Years – 81 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the effect of pre-injection of lidocaine on myoclonus induced by induction with etomidate during general anesthesia in elderly patients

Conditions

• General Anesthesia

Interventions

Type	Name	Description
DRUG	Lidocaine Hydrochloride Injection	Lidocaine injection should be give before the injection of etomidate. In groups L1 and L2, 20 mg and 30 mg lidocaine injection will be diluted to 2ml separately.
DRUG	Etomidate Fat Emulsion Injection	1 minute after the injection of lidocaine, 0.3 mg/kg etomidate will be given in 30 to 60 s.
DRUG	normal saline	2 ml normal saline will be given 1 minute before the injection of etomidate in patients in group C, and in group L1 and L2, normal saline is used to dilute lidocaine injection to 2 ml.
DRUG	Midazolam Injection	0.02 mg/kg midazolam will be given to the patients in all groups 90 s after the injection of etomidate.
DRUG	Fentanyl Citrate Injection	3 μg/kg fentanyl will be given to patients in all groups after the injection of midazolam.
DRUG	Rocuronium Injection	0.6 mg/kg rocuronium will be given to patients in all groups after the injection of fentanyl.

Timeline

• Start date: 2014-05-01
• Primary completion: 2014-10-01
• Completion: 2014-10-01
• First posted: 2014-05-19
• Last updated: 2014-05-19

Locations

1 site across 1 country: China