NCT02140450

Effect of Antiglaucoma Agents on Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection

Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection: the Effect of Pretreatment With Antiglaucoma Agents

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Mashhad University of Medical Sciences · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Accepted

Summary

To assess the effect of prophylactic antiglaucoma agents in prevention of acute intraocular pressure rise after intravitreal injection.

Detailed description

Acute intraocular pressure elevation after intravitreal injection of bevacizumab was proven.Acute intraocular pressure elevation most probably is volume related and long term intraocular pressure elevation relates to pharmacologic features of the medications which results in anatomic changes in the angle of anterior chamber.Numerous studies found an intraocular pressure elevation right after the injection and quick normalization within maximally 30 minutes.This intraocular pressure elevation which lasts about 30 minutes, can result in irreversible visual loss especially in patients with critical remaining nerve fibers in the optic nerve head, as occurs in glaucomatous patients. Is there any way to prevent or even shorten this time of intraocular pressure elevation? We tried in our study to find a suitable response for a question above, so we used several anti-glaucoma agents (Timolol, Brimonidine, Acetazolamide, Mannitol versus placebo) as a prophylaxis to prevent acute intraocular pressure elevation right after intravitreal bevacizumab injection.

Conditions

• Intraocular Pressure Change in Intravitreal Injection

Interventions

Type	Name	Description
DRUG	Timolol	2 drops of timolol, 10 minutes apart, 1-2 hours before intravitreal injection
DRUG	Brimonidine	Brimonidine eyedrop, 2 drops 5 minutes apart, 1-2 hours before intravitreal injection
DRUG	Acetazolamide	Acetazolamide tablet, 2 tabs, 2 hours before intravitreal injection
DRUG	Mannitol	Intravenous mannitol, 1.5 gram/kg, 1 hour before intravitreal injection
DRUG	Placebo	Artificial tears, 2 drops, 1-2 hours before intravitreal injection

Timeline

• Start date: 2012-02-01
• Primary completion: 2014-01-01
• Completion: 2014-05-01
• First posted: 2014-05-16
• Last updated: 2014-05-16

Locations

1 site across 1 country: Iran