Trials / Withdrawn
WithdrawnNCT02137265
Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and Hypoandrogenism
A Randomized, Double-blind, Placebo-controlled Trial of Clomiphene Citrate of Clomiphene Citrate in Hypoandrogenism and Azoospermia
- Status
- Withdrawn
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 0 (actual)
- Sponsor
- University of Illinois at Chicago · Academic / Other
- Sex
- Male
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Hypothesis: Prescribed clomiphene citrate to azoospermic patients with hypoandrogenism could improve the sperm retrieval in either fresh sperm or after surgical sperm extraction.
Detailed description
Hypogonadism (low testosterone level) is frequently observed in men presenting with non obstructive azoospermia. Controversy exists regarding the efficacy of preoperative hormonal manipulation in patients with hypogonadism. However, it is possible that hormonal therapy increases intra-testicular testosterone levels, and with a rise in serum testosterone, sperm production and surgical success with microTESE improve.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Clomiphene | Clomiphene citrate 50 mg orally daily |
| DRUG | Placebo | One pill every other day |
Timeline
- Start date
- 2015-09-01
- Primary completion
- 2020-10-01
- Completion
- 2020-10-01
- First posted
- 2014-05-13
- Last updated
- 2020-10-05
Locations
1 site across 1 country: Spain
Source: ClinicalTrials.gov record NCT02137265. Inclusion in this directory is not an endorsement.