NCT02135965

Testing Potential Synergistic Effects of Albuterol and Caffeine on Metabolic Rate

Testing Potential Synergistic Effects of Albuterol and Caffeine on Metabolic Rate.

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to define a ratio of Caffeine and albuterol that gives a synergistic increase in metabolic rate.

Detailed description

The study consists of 2 screening visits and 8 study visits. Screening visit 1: about 1 hour fasting from 9pm the prior night. Height and weight is measured, vital signs taken and questionnaires completed. Women will have a urine pregnancy test. Blood draw for chemistry panel and blood count. Screening visit 2: about 1 hour, Medical history, physical examination, and electrocardiogram (a heart tracing). Visit 1-8 about 4 hours each. 8 separate occasions, with about 7 days between each visit. ON each visit, blood pressure, pulse and temperature is recorded. A resting metabolic rate (RMR) is measured. After a baseline measurement of about 30 minutes of breathing is taken , a pill will be swallow and metabolism(measured by breathing with a clear plastic hood over the upper body to measure metabolic rate ( the oxygen inhaled and the carbon dioxide exhaled).

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
DRUG	2mg of Albuterol	2mg of Albuterol on metabolic rate
DRUG	4mg of Albuterol	4mg of Albuterol on metabolic rate
DRUG	100mg of Caffeine	100mg of caffeine on metabolic rate
DRUG	200mg of Caffeine	200mg of Caffeine on metabolic rate
DRUG	Albuterol 2mg & Caffeine 100mg	Albuterol 2mg and 100mg of Caffeine
DRUG	Albuterol 2mg and Caffeine 200mg	Albuterol 2mg and Caffeine 200mg on metabolic rate
DRUG	Albuterol 4mg and Caffeine 100mg	Albuterol 4mg and Caffeine 100mg on metabolic rate
DRUG	Albuterol 4mg and Caffeine 200mg	Albuterol 4mg and Caffeine 200mg on metabolic rate

Timeline

• Start date: 2009-04-01
• Primary completion: 2011-08-01
• Completion: 2011-08-01
• First posted: 2014-05-12
• Last updated: 2015-12-18

Locations

1 site across 1 country: United States