NCT02135263

Metabolism of Methylphenidate and Enalapril Based on CES1 Genotype

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether differences in the gene coding for the liver enzyme carboxylesterase 1 (CES1) means differences in the metabolism of two CES1 dependent drugs, enalapril and methylphenidate.

Conditions

• Carboxylesterase 1 (CES1) Genotype
• CES1 Activity

Interventions

Type	Name	Description
DRUG	Methylphenidate	10 mg as a single dose followed by blood samples for the next 33 hours
DRUG	Enalapril	10 mg as a single dose followed by blood samples for the next 72 hours

Timeline

• Start date: 2012-04-01
• Primary completion: 2014-05-01
• Completion: 2014-05-01
• First posted: 2014-05-09
• Last updated: 2014-07-30

Locations

1 site across 1 country: Denmark