NCT02135146

Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 18 Years – 89 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to conduct a prospective, randomized, controlled trial comparing a restrictive vs. conservative fluid strategy in thoracic surgery patients. Excessive perioperative fluid has been retrospectively implicated in the development postoperative acute lung injury (PALI) and pulmonary edema following lung resection. However, fluid restriction in these patients is not without risk and may compromise end organ perfusion (i.e. acute kidney injury). The hypothesis is that a conservative fluid approach in thoracic surgery patients will result in better end organ perfusion with fewer occasions of acute kidney injury (AKI) without causing an increase in postoperative acute lung injury or pulmonary edema.

Conditions

• Hypotension
• Kidney Injury

Interventions

Type	Name	Description
DRUG	Plasmalyte 3ml/kg/hr group	This group will have intravenous plasmalyte fluid limited to a rate of 3 ml/kg/hr. and a nexfin monitor placed on them
DRUG	Plasmalyte 6ml/kg/hr group	This group will have intravenous plasmalyte fluid limited to a rate of 6 ml/kg/hr. and a Nexfix Monitor placed on them

Timeline

• Start date: 2014-01-01
• Primary completion: 2016-09-01
• Completion: 2016-09-01
• First posted: 2014-05-09
• Last updated: 2020-03-03
• Results posted: 2020-03-03

Locations

1 site across 1 country: United States