NCT02134184

The Influence of Chronic CMV Infection on Influenza Vaccine Responses

The Influence of Chronic Cytomegalovirus Infection on Influenza Vaccine Responses

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Accepted

Summary

In this study we are trying to understand whether previous infection with a particular virus, namely cytomegalovirus (CMV), influences the ability of the immune system to respond to new infections or vaccinations with age.

Detailed description

The investigators want to compare the T- and B-cell response to conventional intramuscular trivalent influenza vaccine (TIV) in elderly individuals dependent on the presence and duration of CMV infection by analyses of vaccine-induced plasmablasts, antibodies and antigen-specific T cells. Healthy volunteers, \> 60 years of age, will be identified by the Stanford Blood Center based on their history of positive or negative CMV serologies. Baseline blood samples will be drawn from all study participants prior to immunization. All participants will receive a single dose of 2012-2013 licensed TIV. Volunteers will complete 3 study visits at Day 0, Day 7 and Day 28.

Conditions

• Cytomegalovirus Infections
• Influenza

Interventions

Type	Name	Description
BIOLOGICAL	Fluzone® 2012-2013 Formula NDC No 498281-012-50	This vaccine is given intramuscularly

Timeline

• Start date: 2012-10-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2014-05-09
• Last updated: 2023-04-19
• Results posted: 2016-12-26

Locations

1 site across 1 country: United States