NCT02133950

Efficacy Study of Segmentation of PGD Treatment

A Single Centre Randomised Controlled Study Into the Segmentation of Preimplantation Genetic Diagnosis (PGD) Treatment by Comparing Cumulative Pregnancy Rates Following Cryopreservation of All Genetically Transferable Embryos After PGD, Compared to Fresh Embryo Transfer Cumulative With Frozen Embryo Transfer of Genetically Transferable Embryos.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 252 (estimated)
• Sponsor: Universitair Ziekenhuis Brussel · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

A single centre observational study into the segmentation of preimplantation genetic diagnosis (PGD) treatment by comparing cumulative pregnancy rates following cryopreservation of all genetically transferable embryos after PGD, compared to fresh embryo transfer cumulative with frozen embryo transfer of genetically transferable embryos.The primary aim of the study is to assess the feasibility and effectiveness of segmentation in terms of pregnancy rates. The secondary aim is to assess the logistic advantage of segmentation in PGD cycles. Experimental questions 1. Is the cumulative live birth rate rate of a single PGD treatment when all genetically transferable embryos are cryopreserved by vitrification prior to consecutive in utero transfer in unstimulated cycles, superior to PGD treatment with fresh embryo transfer cumulative with transfer of supernumerary cryopreserved embryos? 2. Does the technique of segmentation allow better planning of DNA amplification and genetic analysis? Design The proposed design is a pragmatic, prospective randomised controlled trial

Conditions

• Clinical Pregnancy
• Live Birth

Interventions

Type	Name	Description
PROCEDURE	elective cryopreservation of available embryos after PGD	no elective fresh embryo transfer; freeze all
PROCEDURE	PGD and elective fresh embryo transfer plus cryopreservation of supernumerary available embryos after PGD	PGD and elective fresh embryo transfer plus cryopreservation of supernumerary available embryos after PGD

Timeline

• Start date: 2014-05-01
• Primary completion: 2016-01-01
• Completion: 2016-01-01
• First posted: 2014-05-08
• Last updated: 2014-05-08

Locations

1 site across 1 country: Belgium