Trials / Completed
CompletedNCT02130154
Brown Adipose Tissue Activity and Age
Brown Adipose Tissue Activity Young and Older Individuals
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 16 (actual)
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Academic / Other
- Sex
- Male
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between young and elderly subjects, as an explanation for the diminished metabolic brown adipose tissue activity in the elderly. The investigators hypothesis is that sympathetic nervous system activity in the elderly is diminished as compared to their younger counterparts as an explanation for the diminished metabolic brown adipose tissue activity in the elderly.
Detailed description
The sympathetic nervous system is the primary activator of Brown Adipose Tissue. Elderly are known to have less metabolically active brown adipose tissue as compared to their younger counterparts. The reason for this diminished metabolic brown adipose tissue activity is unknown. However, a lower sympathetic nervous system activation to brown adipose tissue in the elderly might explain a diminished metabolic brown adipose tissue. Therefore, in this study, both the sympathetic nervous system activation to brown adipose tissue and the metabolic activity will be measured in young and older subjects. sympathetic nervous system activity will be measured using 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scans, metabolic activity will be measured using 18F- fluorodeoxyglucose positron emission tomography CT scans.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | 18-FDG PET CT scan and 123I-MIBG SPECT scan |
Timeline
- Start date
- 2013-05-01
- Primary completion
- 2014-03-01
- Completion
- 2014-03-01
- First posted
- 2014-05-05
- Last updated
- 2014-05-05
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT02130154. Inclusion in this directory is not an endorsement.