NCT02128009

Study on the microRNA Expression Level in Postmenopausal Osteoporosis

Study on the Molecular Mechanism in Postmenopausal Osteoporosis With Kidney Yin Deficiency Syndrome Based on miRNA Mediated Gene Translation Regulation Function by Targeting CLCF1

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Fujian Academy of Traditional Chinese Medicine · Academic / Other
• Sex: Female
• Age: 45 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The miRNA plays an important regulation role in gene expression, and also closely related to bone metabolism. Previous research found that postmenopausal osteoporosis with kidney Yin deficiency syndrome (POP) is associated with CLCF1 gene. This project proposed by bioinformatics prediction CLCF1 targeted regulation of miRNAs, and use the 3 'UTR dual luciferase report system for target validation, aimed at the miRNA levels to explore postmenopausal osteoporosis molecular mechanism with kidney Yin deficiency syndrome.

Conditions

• Postmenopausal Osteoporosis

Interventions

Type	Name	Description
OTHER	osteoporosis

Timeline

• Start date: 2014-02-01
• Primary completion: 2016-12-01
• Completion: 2017-01-01
• First posted: 2014-05-01
• Last updated: 2019-02-26

Locations

1 site across 1 country: China