Trials / Completed
CompletedNCT02124954
A Preliminary Drug Drug Interaction Study With TA-8995
A Phase I, Open Label Study to Assess the Effects of TA-8995 on the Pharmacokinetics of Midazolam and Digoxin in Healthy Male Subjects
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 18 (actual)
- Sponsor
- Xention Ltd · Industry
- Sex
- Male
- Age
- 18 Years – 55 Years
- Healthy volunteers
- Accepted
Summary
A study in healthy males to look at how multiple doses of TA-8995 affect blood levels and rate of removal of other drugs, using single doses of digoxin and midazolam as examples, to see if there are any potential drug interactions that might affect patients in future studies. The study will examine whether co-administration of TA-8995 affects the pharmacokinetics of digoxin and midazolam measured by area under the curve (AUC).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | TA-8995 | |
| DRUG | Midazolam | |
| DRUG | Digoxin |
Timeline
- Start date
- 2014-05-01
- Primary completion
- 2014-07-01
- Completion
- 2014-07-01
- First posted
- 2014-04-28
- Last updated
- 2016-10-03
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT02124954. Inclusion in this directory is not an endorsement.