NCT02123498

The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux

The Study of the Diagnosis of Eustachian Tube Dysfunction (ETD): Identifying the Relationship of Ear Fullness to Laryngopharyngeal Reflux (LPR)

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Loma Linda University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the relationship between ear fullness, pressure, and/or pain and laryngopharyngeal reflux, in order to focus medical therapy and improve therapeutic outcomes in this patient population.

Conditions

• Eustachian Tube Dysfunction
• Laryngopharyngeal Reflux

Interventions

Type	Name	Description
DRUG	Omeprazole	40mg, to be taken once daily by mouth, 30-60 minutes before meals, for at least 6 weeks
DRUG	Ranitidine	300mg, to be taken once daily by mouth, before bedtime, for at least 6 weeks
DRUG	Pantoprazole	40mg, to be taken twice daily by mouth, 30-60 minutes before meals, for at least 6 weeks. (Alternative intervention if participant cannot tolerate omeprazole, is on an anticoagulant medication, or if on medication contraindicated for omeprazole and ranitidine)
PROCEDURE	24-Hour Diagnostic pH-Probe Test	Participants will undergo a routine clinical 24-hour diagnostic pH-probe test to assess quantitative measures for laryngopharyngeal reflux.
PROCEDURE	Laryngoscopy	Participants will undergo routine clinical laryngoscopy to assess presence of laryngopharyngeal reflux.

Timeline

• Primary completion: 2015-05-01
• First posted: 2014-04-25
• Last updated: 2016-09-26

Locations

2 sites across 1 country: United States