NCT02122328

Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome

USFetus Randomized Clinical Trial: Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 642 (actual)
• Sponsor: University of Southern California · Academic / Other
• Sex: Female
• Age: 16 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The investigators hypothesize that treatment of twin-twin transfusion syndrome (TTTS) using sequential laser photocoagulation of communicating vessels (SQLPCV) over the predominant method, selective laser photocoagulation of communicating vessels (SLPCV), may provide vascular stability to the donor fetus. The primary objective is to evaluate the perinatal outcome, specifically, donor intrauterine survival of TTTS managed by SQLPCV vs. SLPCV in a prospective, randomized trial.

Conditions

• Twin Twin Transfusion Syndrome

Interventions

Type	Name	Description
PROCEDURE	Sequential laser photocoagulation of communicating vessels.
PROCEDURE	Selective laser photocoagulation of communicating vessels

Timeline

• Start date: 2010-06-09
• Primary completion: 2023-04-30
• Completion: 2023-10-31
• First posted: 2014-04-24
• Last updated: 2025-07-20

Locations

1 site across 1 country: United States