NCT02116335

Endothelin Receptor Function and Acute Stress

Endothelin Receptor Function and Acute Stress (End-Stress)

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 320 (estimated)
• Sponsor: Augusta University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Our bodies respond differently to stress. Animal studies by the investigators have found that endothelin-1 plays a role in regulating blood pressure in response to stress. This study is an extension of the investigators previous animal work to evaluate the role of endothelin-1 during stress in humans.

Detailed description

Using a salt sensitive animal model of prehypertension, the Dahl S rat,the investigators have previously published that acute stress elicits a pressor response that is accompanied by an increase in 8 isoprostane and endothelin-1. However, the pressor response is suppressed by endothelin A/B receptor antagonism. Moreover, the investigators have identified that the increase in 8-isoprostane occurs downstream of endothelin receptor activation. These data indicate that endothelin receptor activation is a main player In the pressor response to acute stress in pre-hypertensive animals; however, this phenomenon has yet to be elucidated in humans.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	Bosentan	Stress response and vascular function will be assessed 3 days following 125 mg twice per day of Bosentan
DRUG	Placebo	Stress response and vascular function will be assessed 3 days following twice per day placebo

Timeline

• Start date: 2015-06-01
• Primary completion: 2025-12-01
• Completion: 2026-01-01
• First posted: 2014-04-16
• Last updated: 2025-01-28

Locations

1 site across 1 country: United States