Trials / Completed
CompletedNCT02116270
Accelerated Immunosenescence and Chronic Kidney Disease
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 222 (actual)
- Sponsor
- Centre Hospitalier Universitaire de Besancon · Academic / Other
- Sex
- All
- Age
- 18 Years – 85 Years
- Healthy volunteers
- Not accepted
Summary
The aim of this study is to investigate the impact of renal function and dialysis techniques on the percentage of senescent T lymphocytes.
Detailed description
The immunosenescence is a complex and profound remodeling of the immune system during life. It is mainly due to thymic involution and repeated antigenic stimulation. Kidney disease is associated with a decrease in adaptive immunity as evidenced by the decrease in vaccine response and increased susceptibility to infections, similar to those observed in the elderly population. However, data on aging of the immune system in chronic kidney disease remains incomplete. Furthermore, the determinants of immunosenescence are not also not known. It is possible that "uremic" factors help explain the phenotypic and functional changes of lymphocytes, as antigenic stimuli associated with repeated bio-compatible materials used in dialysis contact. The purpose of this study is to describe the phenotypes of the immune system of renal and analyze the determinants of these changes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | Blood sample | 3 tubes of 5 ml tubes and 4 of 7 ml for biological assays at t0. |
Timeline
- Start date
- 2013-09-01
- Primary completion
- 2016-08-01
- Completion
- 2017-01-01
- First posted
- 2014-04-16
- Last updated
- 2018-04-05
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT02116270. Inclusion in this directory is not an endorsement.