NCT02115698

Counteracting Age-related Loss of Skeletal Muscle Mass (CALM)

Counteracting Age-related Loss of Skeletal Muscle Mass

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

Up to 66 healthy elderly individuals (at least 65 years old) are recruited as subjects. They will be recruited as a subgroup to protocol ID: H-4-2013-070. Upon inclusion, each individual will be randomized into one of the five groups stratified according to gender (M/F) and 30s chair stand (\<16 OR ≥16). The five groups are: Heavy Resistance Training (N=12), Light Intensity Training (N=12), Protein Whey (N=15), Protein Collagen (N=15) and Carbohydrate (N=12). The individuals randomized into one of the supplementation groups (Protein Whey, Protein Collagen or Carbohydrate) will be blinded to the supplement content. Assessments will be performed at Baseline (before intervention start) and after 12 months of intervention. The primary outcomes are measures of muscle protein synthesis rate measured as the fractional synthesis rate from Baseline to 12 months of intervention. The hypotheses are i) that basal and protein-stimulated muscle protein synthesis rates are elevated in the exercise training groups after 12 months of intervention. ii) prolonged intake of protein of different quality will improve the muscle protein synthetic response to protein intake after 12 months of intervention.

Conditions

• Sarcopenia
• Muscle Loss

Interventions

Type	Name	Description
PROCEDURE	Heavy Resistance Training	Supervised Heavy Resistance Training three times weekly for 52 weeks.
PROCEDURE	Light Intensity Training	Home-based Light Intensity Training three-five times weekly for 52 weeks.
DIETARY_SUPPLEMENT	Protein Whey	Two daily 20 g whey protein and 10 g carbohydrate supplementations for 52 weeks.
DIETARY_SUPPLEMENT	Protein Collagen	Two daily 20 g collagen protein and 10 g carbohydrate supplementations for 52 weeks.
DIETARY_SUPPLEMENT	Carbohydrate	Two daily 30 g carbohydrate supplementations for 52 weeks.

Timeline

• Start date: 2014-04-01
• Primary completion: 2019-06-01
• Completion: 2019-08-01
• First posted: 2014-04-16
• Last updated: 2023-04-20

Locations

1 site across 1 country: Denmark