Trials / Completed
CompletedNCT02114710
Effects of Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
Study of Little Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 240 (actual)
- Sponsor
- Nanjing PLA General Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 78 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock. And discuss the probable mechanism by which little doses of hydrocortisone influence coagulation system in sepsis.
Detailed description
Patients were randomized to receive either low-dose hydrocortisone or matching placebo.Severity of coagulopathy was estimated using ISTH DIC score. We determined the complications and mortality in two groups, and analyzed the relationship between hydrocortisone and coagulopathy.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Hydrocortisone | Hydrocortisone hemisuccinate (Roussel-Uclaf, Romainville, France), 50 mg intravenously every 6 hrs |
Timeline
- Start date
- 2009-05-01
- Primary completion
- 2012-10-01
- Completion
- 2012-10-01
- First posted
- 2014-04-15
- Last updated
- 2014-04-15
Source: ClinicalTrials.gov record NCT02114710. Inclusion in this directory is not an endorsement.