NCT02114645

The Effect of GnRH Agonist Administered in the Luteal Phase on ART Cycle Outcomes

To Evaluate the Effect of GnRH Agonist Administered in the Luteal Phase on ART Cycle Outcomes in Both GnRH Agonist and GnRH Antagonist Treated Ovarian Stimulation Protocols

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Zekai Tahir Burak Women's Health Research and Education Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 38 Years
• Healthy volunteers: Accepted

Summary

This prospective clinical trial evaluates the effect of a two dose GnRH agonist administered in the luteal phase on the outcome of ART cycles stimulated with the long GnRH agonist and GnRH antagonist protocol.

Detailed description

This prospective clinical trial evaluates the effect of a two dose GnRH agonist administered in the luteal phase on the outcome of ART cycles stimulated with the long GnRH agonist and GnRH antagonist protocol. Decision between each of these two protocols was subjective and depended on the clinical context.In addition to routine luteal phase support with progesterone and estradiol valerate,women received two dose of GnRH agonist on the fifth and tenth day after ET.Live birth rate was the primary outcome measure.

Conditions

• Infertility

Interventions

Type	Name	Description
DRUG	Leuprolide acetate	in experimentals groups,on fifth and tenth day after embryo transfer 0,5mg leuprolide acetate is given subcutaneously as luteal phase support
DRUG	vaginal progesterone	crinone gel is applied till fetal heart beat is detected
DRUG	4 mg oral estradiol valerate	estrofem is given twice a day

Timeline

• Start date: 2014-04-01
• Primary completion: 2015-02-01
• Completion: 2015-04-01
• First posted: 2014-04-15
• Last updated: 2014-04-15

Locations

1 site across 1 country: Turkey (Türkiye)