NCT02112864

Dexamethasone for Reduction of Post Thoracotomy Pain Syndrome

Impact of Dexamethasone on the Post Operative Inflammatory Response and on the Occurrence of Post Thoracotomy Pain Syndrome

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Maisonneuve-Rosemont Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Post thoracotomy pain syndrome still affects 50% of patients after a thoracic surgery. Pathogenesis is unclear but there is growing evidence that neuro inflammation may play a significant role. Dexamethasone is a very potent anti-inflammatory drug. The hypothesis of this study is that dexamethasone, given pre operatively, would help reduce the incidence of post thoracotomy pain syndrome 3 months after surgery, by reducing the inflammatory response, in patients undergoing elective thoracic surgery that includes thoracic epidural analgesia.

Conditions

• Chronic Pain
• Dexamethasone
• Thoracic Surgery
• Cytokines

Interventions

Type	Name	Description
DRUG	Dexamethasone	10 mg (2.5 ml)
DRUG	Normal Saline	2.5 mL normal saline

Timeline

• Start date: 2014-05-01
• Primary completion: 2024-12-01
• Completion: 2025-07-01
• First posted: 2014-04-14
• Last updated: 2023-03-20

Locations

1 site across 1 country: Canada