NCT02107170

Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 68 (actual)
• Sponsor: Tao Zhang · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital. The effects of anesthetic agents on postoperative outcome, especially cognitive function, are not clear. In this study investigators propose to measure postoperative cognitive function and other outcome of patients who are undergoing these two kinds of surgeries, and try to identify whether there is an association between different kinds of anesthetics and postoperative outcome. Investigators will also observe whether changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6, are associated with postoperative delirium or cognitive change.

Conditions

• Endovascular Repair of Aortic Aneurysm
• Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities

Interventions

Type	Name	Description
DRUG	Sevoflurane	sevoflurane-based general anesthesia
DRUG	Propofol	total intravenous anesthesia
DRUG	Remifentanil

Timeline

• Start date: 2014-02-01
• Primary completion: 2017-10-01
• Completion: 2017-12-01
• First posted: 2014-04-08
• Last updated: 2018-06-12

Locations

1 site across 1 country: China