NCT02105493

Nitroglycerin Prevents Radial Artery Occlusion

A Novel Approach to Reduce Radial Artery Occlusion After Trans-Radial Catheterization: Post-Procedural/Pre-Hemostasis Intra-Arterial Nitroglycerin

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,706 (actual)
• Sponsor: National Cardiovascular Center Harapan Kita Hospital Indonesia · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Trans-radial approach (TRA) has becoming popular and widely adopted over the last decade. However, radial artery occlusion (RAO) continues to be one of the limitation of trans-radial access and potentially limits the radial artery as an access site in the future. Several strategies have been used to decrease the incidence of RAO including the use of anticoagulation, maintenance of patency during hemostasis, or shortening the duration of compression. Currently, there is no data whether vasoactive pharmacological therapy such as nitroglycerin administered intra-arterially at the end of the procedure may reduce the incidence of RAO. It is hypothesized that the addition of nitroglycerin (nitric oxide donor) at the end of a TRA procedure may reduce the incidence of RAO.

Conditions

• Injury of Radial Artery

Interventions

Type	Name	Description
DRUG	500 microgram of Nitroglycerin	500 microgram of Nitroglycerin (in 5 mL saline) given intra-arterially through the sheath at the end of transradial procedure
DRUG	Saline 5 mL	Saline 5 mL given intra-arterially through the sheath at the end of transradial procedure

Timeline

• Start date: 2013-10-01
• Primary completion: 2014-02-01
• Completion: 2014-03-01
• First posted: 2014-04-07
• Last updated: 2014-04-07

Locations

1 site across 1 country: Indonesia