NCT02101437

The Relationship of Platelet Micro-RNA Expression and Platelet Reactivity in Patients Under Clopidogrel or Ticagrelor Treatment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 175 (actual)
• Sponsor: Taipei City Hospital · Other Government
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

For acute coronary syndrome patients undergoing cardiac catheterization after stenting, we will give dual antiplatelet drugs (dual antiplatelet agents) therapy, the choice of the basis of medical criteria (clinical guidelines) routine as aspirin + clopidogrel or aspirin + ticagrelor, according to medical guidelines currently no other disposal alternative proposal (unless adverse drug tolerance or bleeding can not be administered); idea of this experiment for acute coronary syndrome or conventional cardiac catheterization after stenting, platelet miRNA expression (miR-96 , miR-200b, miR-495, miR-107) after cardiac catheterization and interventional treatment of clopidogrel or ticagrelor acceptance of platelet reactivity (PRU) correlation values (given clopidogrel or ticagrelor determined by the clinician, the patient follow-up experiment to track only and observation), aims to explore under different platelet reactivity (hyper-reactive or hypo-reactive), their differences in miRNA performance.

Conditions

• PRU
• miRNA

Interventions

Type	Name	Description
PROCEDURE	miRNA within 24hr	miRNA within 24hr
PROCEDURE	miRNA after 1 week	miRNA after 1 week
PROCEDURE	miRNA after 1 month	miRNA after 1 month

Timeline

• Start date: 2014-01-01
• Primary completion: 2014-06-01
• Completion: 2017-11-01
• First posted: 2014-04-02
• Last updated: 2019-08-28
• Results posted: 2019-08-28

Locations

1 site across 1 country: Taiwan