NCT02099929

Effects of Coffee Consumption on Glucose Metabolism

Coffee and Glucose Metabolism: Clinical, Crossover and Randomized Glucose Disposal Assay Using Stable Isotopes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: University of Brasilia · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Epidemiological studies have shown an inverse association between coffee consumption and risk of type 2 diabetes mellitus (T2DM). However the experimental studies that analysed the mechanisms are limited. This project aims to assess the effects of coffee consumption on glucose metabolism, using stable isotope tracer (13C-glucose) to explain the possible metabolic mechanisms involved on the reduced risk for T2DM.

Detailed description

This is a crossover randomized clinical trial that has been studying 14 male healthy young adults, who were enrolled five treatments: coffee with sugar, coffee without sugar, decaffeinated coffee without sugar and two controls (water with and without sugar). The stable isotope minimal model protocol with oral glucose administration (Oral Dose Intravenous Label Experiment - ODILE) was performed. The use of ODILE methodology permits separation of the glucose absorbed and removed from the circulation increasing the accuracy and the effectiveness of glucose uptake and insulin sensitivity (Bluck et al., 2006).

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Coffee with Sugar	300mL of Coffee with 30g of Sugar
OTHER	Coffee without Sugar	300mL of Coffee without Sugar
OTHER	Decaffeinated Coffee without Sugar	300mL of Decaffeinated Coffee without Sugar
OTHER	Water with Sugar	300mL of Water with 30g of Sugar
OTHER	Water without Sugar	300mL of Water without Sugar

Timeline

• Start date: 2012-06-01
• Primary completion: 2013-12-01
• Completion: 2013-12-01
• First posted: 2014-03-31
• Last updated: 2014-03-31

Locations

1 site across 1 country: Brazil