NCT02097368

Bulbar Function in Neuromuscular Patients

Prospective Evaluation of Bulbar Function in Neuromuscular Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Centre d'Investigation Clinique et Technologique 805 · Academic / Other
• Sex: All
• Age: 6 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The main objective is prospectively study the upper airways function in an adult population of neuromuscular patients. The main measurement will be the evolution of tongue strength recorded each year during annual clinical evaluation on a 5 years period.

Detailed description

The main objective is to study the function of the superior airways (tongue and pharynx) in an non invasive way in neuromuscular patients followed in the home ventilation unit of the Raymond POINCARE hospital (myopathy, neuropathy, disease of the neuromuscular junction or anterior horn) or of Necker Hospital and to detect prematurely the bulbar dysfunction. The secondary objectives of this prospective monocentric observational physiopathological study are: 1. to study the correlation between the possible swallowing dysfunction and the anomalies of the respiratory parameters 2. to establish correlations between infraclinical or clinical and presence of morphological tongue anomalies detected by magnetic resonance imaging like in acid maltase deficiency. The maximal tongue strength protrusion will be measured according to a method already used in the laboratory to explore sleep apnea syndromes. Swallowing will be estimated by a non invasive method already used to highlight swallowing disorders in neurological and muscular pathologies This method will be associated with a method of recording of thoracic and abdominal movements. Data wil be compared to a control database obtained for a previous study

Conditions

• Neuromuscular Diseases

Interventions

Type	Name	Description
PROCEDURE	tongue strength measurement	tongue strength measurement
PROCEDURE	respiratory function measurement	respiratory function measurement
PROCEDURE	swallowing tests	swallowing tests
OTHER	Magnetic resonance imaging	Magnetic resonance imaging

Timeline

• Start date: 2014-04-01
• Primary completion: 2019-01-01
• Completion: 2020-12-01
• First posted: 2014-03-27
• Last updated: 2018-01-25

Locations

2 sites across 1 country: France