NCT02095873

Healthy Aging Through Functional Food

Dietary Inducers of Glyoxalase-1 for Prevention and Early-stage Alleviation of Age Related Health Disorders Through Functional Foods.

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: University of Warwick · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether dietary inducers of glyoxalase 1 are effective in improving metabolic and vascular health.

Detailed description

The aim of the study is to evaluate dietary inducers of glyoxalase 1 for effects on metabolic and vascular health in overweight volunteers at risk of developing type 2 diabetes. The research objectives are: (i) To evaluate dietary inducers of glyoxalase 1 for effects on markers of glucose metabolism during an oral glucose tolerance test (oGTT), (ii) To evaluate dietary inducers of glyoxalase 1 for effects on vascular function on three levels, using finger fold capillary density by capillaroscopy (FFCD), arterial stiffness by aortal pulse wave velocity (aPWV) and flow mediated dilatation (FMD); and effects on metabolic and pro-inflammatory markers in circulating blood and urine.

Conditions

• Glucose Intolerance
• Aortic Stiffness
• Vasodilation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Glyoxalase 1 (Glo1) inducer	Dietary bioactive
DIETARY_SUPPLEMENT	Placebo	Mannitol, 108 mg

Timeline

• Start date: 2014-05-01
• Primary completion: 2015-02-01
• Completion: 2015-05-01
• First posted: 2014-03-26
• Last updated: 2017-03-06
• Results posted: 2017-03-06

Locations

1 site across 1 country: United Kingdom