Trials / Completed
CompletedNCT02094664
Heated Humidified Oxygen Compared to Dry Oxygen Therapy in Children With Bronchiolitis
HHOT AIR Study (a Pilot Study): Heated Humidified Oxygen Therapy Compared to Standard Dry Oxygen: An Assessment in Infants With bRonchiolitis
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 32 (actual)
- Sponsor
- UCSF Benioff Children's Hospital Oakland · Academic / Other
- Sex
- All
- Age
- 24 Months
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to compare heat and humidified oxygen with cold and dry oxygen in children with bronchiolitis. The hypotheses are that heating and humidifying inspired low flow supplemental oxygen will optimize mucociliary function thereby, 1) improve oxygenation, 2) decrease work of breathing, and 3) decrease length of hospital stay.
Detailed description
Bronchiolitis is the leading cause of acute respiratory illness and hospitalization in infants and young children. The mainstay of treatment is supportive care, which includes frequent nasal suctioning, intravenous fluid hydration, and supplemental oxygen for hypoxemia. The airways normally heat and humidify inspired ambient air to core temperature amd 100% relative humidity at the carina. This environment, at core temperature, allows for optimal mucociliary clearance. Supplemental oxygen delivered via wall source is cold and dry, and does not reach core temperature and 100% humidity until some point distal to the carina, past the main bronchi. This presses on the lower respiratory tract to assist in heat and moisture exchange and thus decrease ciliary function. This, in combination with bronchiolitis, can impair mucociliary clearance. Specific aim 1: Determine the effect of heated and humidified oxygen therapy on clinical improvement in children with bronchiolitis, based on Respiratory Distress Assessment Instrument (RDAI) and respiratory rate (RR). Specific aim 2: Determine the effect of heated and humidified oxygen therapy on length of hospital stay and duration of supplemental oxygen requirement in children with bronchiolitis.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Heated and humidified oxygen |
Timeline
- Start date
- 2014-01-01
- Primary completion
- 2015-06-01
- Completion
- 2015-06-01
- First posted
- 2014-03-24
- Last updated
- 2018-01-08
- Results posted
- 2018-01-08
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02094664. Inclusion in this directory is not an endorsement.