NCT02094066

The Effect of Tranexamic Acid for Total Hip Arthroplasty

The Effects of High Doze Tranexamic Acid Application on Hemorrhage, Blood Transfusion, Fibrin Degradation Products, and Kidney Functions for Total Hip Arthroplasty

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: TC Erciyes University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to investigate the effects of tranexamic acid on hemorrhage, blood transfusion, fibrin degradation products and kidney functions for total hip arthroplasty.

Detailed description

Orthopedic surgery may be associated with substantial blood loss requiring transfusion of erythrocytes.Transfusion of allogeneic erythrocytes is not free of adverse events and has been associated with transmission of infectious diseases, increased postoperative bacterial infection, immune sensitization, and transfusion related acute lung injury. Measures taken to allay concerns about the safety of blood transfusions have translated into the increasing cost of allogeneic blood units. Blood banks regularly undergo blood shortages. For these reasons, there is a need to reduce allogeneic blood transfusions. A number of effective interventions have been developed, such as preoperative autologous donation, cell salvage, or the use of erythropoietin. Pharmacologic agents such as aprotinin, tranexamic acid, or epsilon-aminocaproic acid (EACA) could reduce perioperative blood loss by interfering with fibrinolysis.

Conditions

• Hemorrhage

Interventions

Type	Name	Description
DRUG	tranexamic acid	preoperative ıv 50 mg/kg tranexamic acid infusion at 45 minutes
DRUG	serum physiologic	preoperative 100 cc ıv serum physiologic

Timeline

• Start date: 2014-03-01
• Primary completion: 2014-06-01
• Completion: 2014-07-01
• First posted: 2014-03-21
• Last updated: 2014-03-26

Locations

1 site across 1 country: Turkey (Türkiye)