NCT02093572

Effect of Skipping Breakfast on Metabolic Function

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to test the hypothesis that the disruption of the "normal" (three meals a day) eating pattern and prolonged overnight fasting caused by skipping breakfast: i) alters the expression of specific clock genes and clock gene targets involved in regulating adipose tissue lipolysis (breakdown or destruction); ii) increases basal adipose tissue lipolytic (breakdown) activity and plasma free fatty acid (FFA) concentrations; iii) reduces skeletal muscle insulin sensitivity; and iv) increases daylong plasma glucose, FFA, and insulin concentrations. The investigator will do this by studying healthy, lean persons either randomized to consume either 3 standard meals per day or omit breakfast and consume 2 meals per day without changing daily calorie intake (skipping breakfast group).

Conditions

• Skipping Breakfast
• Circadian Rhythms

Interventions

Type	Name	Description
OTHER	3 standard meals/day
OTHER	2 meals/day (omit breakfast)

Timeline

• Start date: 2014-05-01
• Primary completion: 2017-05-05
• Completion: 2017-05-05
• First posted: 2014-03-21
• Last updated: 2021-03-26

Locations

1 site across 1 country: United States