NCT02091349

Tolerance and Utilization of Polydextrose, Inulin, and Soluble Corn Fiber

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: University of Illinois at Urbana-Champaign · Academic / Other
• Sex: Male
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to determine the tolerance and utilization of polydextrose and soluble corn fiber through analyses of fecal samples of fermentative end-products (short-chain fatty acids, ammonia, phenol, and indole) and shifts in microbial populations.

Detailed description

Soluble fibers have been shown to have many positive effects in humans, including laxation and maintaining gastrointestinal health. It is expected that feeding soluble fibers will decrease protein fermentative end=products while increasing carbohydrate fermenative end-products, and lead to a more beneficial microbial profile. Determination of the effects of nutriose and polydextrose when included as supplemental fiber in a human diet will give insights to its potential to maintain or improve gut health and highlight its use in the food industry. The object of this study are first to determine the tolerance of soluble fibers polydextrose, inulin and nutriose when provided as supplemental fiber to an existing diet. The second objective is to determine the utilization of polydextrose and nutriose through analyses of fecal samples of fermentative end-products and shifts in microbial populations.

Conditions

• Tolerance

Interventions

Type	Name	Description
OTHER	polydextrose	polydextrose- 7, 14, or 21 grams/day 3X3 latin square with 3 periods
OTHER	soluble corn fiber	nutirose- 7, 14, or 21 grams/day

Timeline

• Start date: 2010-07-01
• Primary completion: 2011-01-01
• Completion: 2012-07-01
• First posted: 2014-03-19
• Last updated: 2014-05-14