NCT02090998

Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines

A Comparison of the Efficacy of 5% Lidocaine Anesthetic to Provide SPGB Vs. Elavil for the Treatment of Transformed Migraine

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Rutgers, The State University of New Jersey · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will compare a local anesthetic technique that has been used to treat subjects suffering from transformed migraines (chronic migraines) versus medical management with traditional antidepressant Amitriptyline / Elavil. Subjects will be randomized into one of two treatment groups to compare the safety and efficacy of the therapies. Subjects will recieve either sphenopalatine ganglion nerve block with 5% lidocaine gel into the nasopharynx or medical management with traditional antidepressants, Elavil, to produce a reduction in the frequency and severity of the headache. We propose that there will be a difference in the outcomes when comparing the two methods of treating transformed migraines and that one research arm will result in more patient satisfaction and greater efficacy in the treatment of subjects

Detailed description

Arm one will receive Sphenopalatine Ganglion Nerve Block weekly for 4 weeks Arm two will receive Amitriptyline / Elavil daily for 30 Days

Conditions

• Transformed Migraine
• Chronic Daily Headache

Interventions

Type	Name	Description
PROCEDURE	SPG Block with 5% Lidocaine gel	cotten tipped applicators are with 5% lidocaine gel and placed in the nares to lye in the skin over the sphenopalitine ganglion. The applcator is use to saturate the spenopalitine ganglion with 5ml of 1% lidocaine local anesthesia
DRUG	Amitriptyline	The intervention will be Amitriptyline daily (starting with 10 mg) PO for 30 Days

Timeline

• Start date: 2014-05-01
• Primary completion: 2020-03-16
• Completion: 2020-03-16
• First posted: 2014-03-19
• Last updated: 2024-07-16
• Results posted: 2021-12-29

Locations

1 site across 1 country: United States