NCT02088853

Diet Induced Intestinal Mucosal Adaptation

Small Intestinal Adaptation to Isocaloric Diets Dominated Either by Fats or Carbohydrates

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Göteborg University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Human beings are 'omnivores' meaning that all principal components of food (i.e. the macronutrients: carbohydrates, fat, proteins) can be assimilated by the gastrointestinal tract. When the gut mucosa is exposed to dietary changes it adjusts its functional behaviour. For example, a fatty diet demands certain digestive mechanisms, whereas others are needed to take care of a carbohydrate rich diet. Such dietary induced changes in appearance and functionality of the small intestinal mucosa have been described in animals but only little is known about it in man. The present project aims at elucidating in man if a 2 weeks diet dominated by either fat or carbohydrates, but with similar energy content, is associated with changes in the small intestinal mucosal appearance and metabolic signalling capacity.

Conditions

• Healthy Conditions

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	high fat diet (hfd), then high carbohydrate diet	Sixty % of the energy content is based on fat, then sixty % of the energy content is based on carbohydrates
DIETARY_SUPPLEMENT	high carbohydrate diet, then high fat diet	Sixty % of the energy content is based on carbohydrates, then sixty % of the energy content is based on fat

Timeline

• Start date: 2014-03-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2014-03-17
• Last updated: 2025-07-17
• Results posted: 2025-07-17

Locations

1 site across 1 country: Sweden