Trials / Unknown
UnknownNCT02087930
Microbiota as Potential Target for Food Allergy
Microbiota as Potential Target for Innovative Preventive and Therapeutic Strategies for Food Allergy
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 600 (estimated)
- Sponsor
- Federico II University · Academic / Other
- Sex
- All
- Age
- 6 Months – 12 Months
- Healthy volunteers
- Not accepted
Summary
Food allergy (FA) derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for enteric microflora in oral tolerance development. An altered composition of intestinal microflora results in an unbalanced local and systemic immune response to food allergens. There are qualitative and quantitative differences in gut microbiota composition in children with food allergy. These findings support the concept that specific beneficial bacteria from human intestinal microflora, designated probiotics, could restore intestinal microflora homeostasis and prevent or treat FA.
Conditions
Timeline
- Start date
- 2013-03-01
- Primary completion
- 2020-05-01
- Completion
- 2020-09-01
- First posted
- 2014-03-14
- Last updated
- 2018-05-29
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT02087930. Inclusion in this directory is not an endorsement.