NCT02087280

Metabolic Phenotyping in Anorexia Nervosa

Metabolic Phenotyping to Predict Risk of Relapse in Patients With Anorexia Nervosa

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: Female
• Age: 12 Years – 18 Years
• Healthy volunteers: Accepted

Summary

After discharge from inpatient treatment, 30-50% of patients with Anorexia Nervosa require re-hospitalization within 4-12 months. So far, high relapse rates are mostly considered as lack of the patient's compliance and motivation to recover. However in studies, psychological relapse predictors explain only a minor part of the variance in relapse risk. Metabolic phenotyping has clinical value to predict weight course in obese patients and we assume that it could also be clinically relevant in patients with AN. We hypothesize that in patients with a dissipative but not with the thrifty phenotype, positive energy balance during refeeding causes an over proportional rise in energy expenditure, counteracts continuous weight gain during inpatient treatment, and increases relapse risk within one year after discharge. Thus we believe that metabolic phenotype as a biological parameter has prognostic value for the disease course in AN.

Conditions

• Anorexia Nervosa

Timeline

• Start date: 2014-10-01
• Primary completion: 2016-08-01
• Completion: 2016-08-01
• First posted: 2014-03-14
• Last updated: 2017-02-13

Locations

1 site across 1 country: Germany