NCT02084355

Study of Opioid Rotation Versus Opioid Escalation in Patients With Moderate to Severe Cancer Pain

Efficacy and Safety of Opioid Rotation Compared With Opioid Dose Escalation in Patients With Moderate to Severe Cancer Pain - Open Label, Randomized, Prospective Study

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 136 (estimated)
• Sponsor: Gyeongsang National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Although opioid rotation is well known treatment modality in reducing pain and opioid-induced neurotoxicity, it is not established whether opioid rotation is more appropriate or opioid escalation is more effective in controlling significant pain in cancer patients under opioid medication. \- The purpose of this study is to determine effective therapy out of opioid rotation and opioid dose escalation in patients with moderate to severe cancer pain who have been already treated with strong opioid.

Conditions

• Cancer
• Pain

Interventions

Type	Name	Description
DRUG	oral oxycodone
DRUG	oral hydromorphone
DRUG	fentanyl patch

Timeline

• Start date: 2014-04-01
• Primary completion: 2015-12-01
• Completion: 2016-01-01
• First posted: 2014-03-12
• Last updated: 2014-03-12

Locations

1 site across 1 country: South Korea