Trials / Completed
CompletedNCT02083692
Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling
Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling.
- Status
- Completed
- Phase
- EARLY_Phase 1
- Study type
- Interventional
- Enrollment
- 50 (actual)
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to assess the effect of metformin in tumor metabolism in patients with head and neck cancer by evaluating metformin's ability to decrease TOMM20 expression in squamous carcinoma cells and decrease MCT4 expression in fibroblasts.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Metformin |
Timeline
- Start date
- 2013-09-05
- Primary completion
- 2016-05-09
- Completion
- 2017-04-06
- First posted
- 2014-03-11
- Last updated
- 2025-05-15
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02083692. Inclusion in this directory is not an endorsement.