NCT02083367

Default Mode Network fMRI Maps as a Predictive Index of Hepatic Encephalopathy Outcome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 12 (actual)
• Sponsor: OSF Healthcare System · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Investigating the impact of hepatic encephalopathy on default mode networks within the brain to provide more clues with understanding the physiology of consciousness and predicting the reversibility of comatose states.

Detailed description

The proposed study will provide better understanding of the patterns of default mode network (DMN) dysfunction in comatose state of hepatic encephalopathy, may help to further define the boundaries of neuronal circuits involve, and will try to assess the prognostic value of fMRI in reversibility of severe metabolic coma.

Conditions

• Hepatic Encephalopathy
• Cirrhosis
• Nonalcoholic Steatohepatitis
• Hepatitis C

Timeline

• Start date: 2013-01-01
• Primary completion: 2014-10-01
• Completion: 2015-02-01
• First posted: 2014-03-11
• Last updated: 2015-05-25

Locations

1 site across 1 country: United States