Trials / Terminated
TerminatedNCT02083146
C1q/TNF-related Proteins in Coronary Artery Disease
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 362 (actual)
- Sponsor
- Korea University · Academic / Other
- Sex
- All
- Age
- 20 Years – 80 Years
- Healthy volunteers
- Accepted
Summary
Now, adipose tissue is established as an active endocrine organ that controls systemic energy homeostasis by secretion of adipokines. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and coronary artery disease (CAD) in Korean men and women.
Detailed description
Adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the development of obesity-related disorders including cardiovascular disease (CVD). Adiponectin is the insulin-sensitizing adipokine with anti-inflammatory and anti-atherogenic properties. Hypoadiponectinemia has been associated with an increased risk of coronary artery disease (CAD) in several though not all studies. Recently, a new family of secreted proteins, C1q/TNF-related protein (CTRP), was cloned on the basis of sequence homology with adiponectin. This family of adiponectin paralogs might have pivotal implications in energy homeostasis and obesity-related inflammation. Each CTRP family member has its own unique tissue expression profile and function in regulating glucose and/or fat metabolism. In the present study, we evaluated the role of CTRP in patients with CAD and investigated whether CTRP family is significantly associated with CAD prevalence after adjustment for well-known CAD risk factors.
Conditions
Timeline
- Start date
- 2011-03-01
- Primary completion
- 2012-12-01
- Completion
- 2016-02-01
- First posted
- 2014-03-11
- Last updated
- 2018-03-20
Locations
1 site across 1 country: South Korea
Source: ClinicalTrials.gov record NCT02083146. Inclusion in this directory is not an endorsement.