NCT02078128

To Study the Effect of β-glucans on Wound Healing

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: National Taiwan University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the effect of β-glucans on wound healing.

Detailed description

The structure of βeta-glucan (β-glucans) is a pathogen associated molecular patterns (pathogen-associated molecular patterns, PAMPs), widely present in the cell walls of plants, bacteria, yeasts, fungi, mushrooms and algae. Modern has been reported in the literature that β-glucan can enhance the immune system of animals, and to enhance the function of the animal against bacterial, fungal and viral infections, and cancer.In this study, the use of β-glucan to enhance the biological characteristics of the non-specific immunity, to explore the impact of postoperative patients with wound healing and infection rates.The observation of the healing process to take the Leather District wounds (5 \~ 200 cm2). The experiments were carried out for 18 months, were observed record the following three: (1) the rate of wound healing, (2) The rate of infection assessment: record length of time and the point in time at all levels of antibiotic use also observe the wound change (redness, swelling, heat, pain).(3) days of hospitalization, and spend statistics. Using unpaired student's t-test analysis, group data whether the differences between groups of experimental data. represents a statistically significant when p \<0.05.

Conditions

• Burns

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	oral beta-glucans	30 mg/kg, oral every day until wound healed completes or unacceptable toxicity develops.
DRUG	oral sugar powder	30 mg/kg, oral every day until wound healed completes or unacceptable toxicity develops.

Timeline

• Start date: 2011-07-01
• Primary completion: 2011-08-01
• Completion: 2013-02-01
• First posted: 2014-03-05
• Last updated: 2014-03-05

Locations

1 site across 1 country: Taiwan