NCT02071615

Effects of Modafinil, Caffeine and Methylphenidate in Healthy Volunteers

Effects of Modafinil, Caffeine and Methylphenidate on Functional Brain Activity and Cognitive Performance in Healthy Volunteers: a Randomized, Placebo-controlled, Double-blind fMRI Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

In this study the investigators compare three stimulants to each other. The effects of these agents on cognitive performance (eg, attention and memory) and on the brain are being measured. The hypothesis is that stimulants will have a positive effect on cognitive performance. Each study participant will receive once a placebo and once methylphenidate or modafinil or caffeine. Methylphenidate (also known as Ritalin ®) is a drug that is used in the treatment of attention deficit / hyperactivity disorder (ADHD) in children, adolescents and adults. Modafinil ( Vigil ®) is a drug used in the treatment of narcolepsy (sleeping sickness). In the study. These substances are given in the study only once and in the dosages in which is also used for the treatment of the above diseases. In the case of caffeine , the dosage corresponds to two cups of coffee.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Methylphenidate 20 mg tablet given once by mouth	3-arm, single-drug dosage comparison study
DRUG	modafinil 200mg tablet given once by mouth	3-arm, single-drug dosage comparison study
DRUG	caffein 200mg tablet given once by mouth	3-arm, single-drug dosage comparison study
DRUG	placebo

Timeline

• Start date: 2013-08-01
• Primary completion: 2014-03-01
• Completion: 2014-03-01
• First posted: 2014-02-26
• Last updated: 2014-04-17

Locations

1 site across 1 country: Germany