NCT02070224

Evaluation of the Prognostic Value of Biological Markers, Coll2-1 and Coll2-1NO2 in Patients With Symptomatic Knee Osteoarthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Artialis · Industry
• Sex: All
• Age: 45 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purposes of this study are to assess the prognostic value of serum and urinary biomarkers Coll2-1 and Coll2-1NO2 at baseline, and their change over the first year, on the progression of knee osteoarthritis MRI scores at 12 months, on the progression of knee osteoarthritis clinical score at 12 months. Additionally, this study will search for correlations between serum and urinary biomarkers Coll2-1 and Coll2-1NO2 at baseline with the radiographic, MRI and clinical severity of knee osteoarthritis.

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
OTHER	Serum and urine samples collections	Serum and urine samples will be collected at baseline, 3 month, 6 month, 12 month to assess the predictive value of cartilage-specific biomarkers Coll2-1/Coll2-1NO2 on OA progression (MRI, Clinical and radiological progression)
OTHER	Imaging (x-rays and MRI)	MRI will be done at baseline and 12 month and x-rays will be done at baseline

Timeline

• Start date: 2014-01-01
• Primary completion: 2019-02-01
• Completion: 2019-02-01
• First posted: 2014-02-25
• Last updated: 2019-02-05

Locations

2 sites across 2 countries: Belgium, France