NCT02070133

Efficacy of Simvastatin for the Treatment of COPD

Pilot Study on the Efficacy of Statins for the Treatment of Chronic Obstructive Pulmonary Disease

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Hospital Universitari Son Dureta · Academic / Other
• Sex: Male
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

To evaluate in patients with stable Chronic Obstructive Pulmonary Disease (COPD) the efficacy of statins (simvastatin) on: (1) endothelial function; (2) systemic inflammation; (3)BODE (B: body mass , O: bronchial obstruction, D: dyspnea and, E: exercise tolerance) index; (4) Uric acid; and, (5)vascular growth factors. Design: a 12 weeks randomized (1:1), double-blind, placebo control study. Population: 18 males with stable COPD between 40-80 years of age, exsmokers, with Forced expiratory volume in one second (FEV1) between 30 and 80% predicted post-bronchodilation.

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

Type	Name	Description
DRUG	Simvastatin	Simvastatin 40 mg once a day during 12 weeks
DRUG	Placebo	Placebo once a day during 12 weeks

Timeline

• Start date: 2009-05-01
• Primary completion: 2013-03-01
• Completion: 2013-05-01
• First posted: 2014-02-25
• Last updated: 2014-02-25

Locations

2 sites across 1 country: Spain