NCT02068482

Immunohistology in USDD and Correlation Between Bacterial Flora and Phlogosis

Evaluation of Immunohistological Pattern in Patients With Uncomplicated Symptomatic Diverticular Disease and Correlation Between Intraluminal Bacterial Flora and Phlogosis

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 61 (actual)
• Sponsor: Catholic University of the Sacred Heart · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Diverticulosis of the colon is a frequent condition in adults in western countries and a significant number of patients experience clinical symptoms even when the diverticulosis is not complicated by diverticulitis. Both central and mucosal immunity are altered in Uncomplicated Symptomatic Diverticular Disease (USDD) and Rifaximin ameliorate clinical symptoms and normalize the immunological abnormalities. The Study Protocol is verify the modifications in the immunological pattern induced by reducing bacteria related activation of immunity by Rifaximin treatment.

Conditions

• Diverticular Disease

Interventions

Type	Name	Description
DRUG	Rifaximin	Rifaximin 200 mg 6 tbs per day per 15 days/ month for 2 months

Timeline

• Start date: 2010-11-01
• Primary completion: 2012-05-01
• Completion: 2012-08-01
• First posted: 2014-02-21
• Last updated: 2014-02-21

Locations

1 site across 1 country: Italy