Clinical Trials Directory

Trials / Terminated

TerminatedNCT02068157

Interstitial Photodynamic Therapy in Treating Patients With Recurrent Head and Neck Cancer

Interstitial Photodynamic Therapy During Standard Chemotherapy for Palliation of Patients With Head and Neck Squamous Cell Carcinoma - Phase II

Status
Terminated
Phase
Phase 2
Study type
Interventional
Enrollment
3 (actual)
Sponsor
Roswell Park Cancer Institute · Academic / Other
Sex
All
Age
18 Years
Healthy volunteers
Not accepted

Summary

This phase II trial studies the effects of interstitial photodynamic therapy in patients with head and neck cancer that has come back. Interstitial photodynamic therapy uses a combination of laser light and a light-sensitive drug called porfimer sodium to destroy tumors. During treatment a laser light is used to activate the drug. Interstitial photodynamic therapy may be an effective treatment for head and neck cancer.

Detailed description

PRIMARY OBJECTIVES: I. Demonstrate that our image-guided interstitial photodynamic therapy (I-PDT) dosimetry system can be used to tailor this therapy to individual patients. OUTLINE: Patients receive porfimer sodium intravenously (IV) over 3-5 minutes on day 0. Patients then undergo image-guided I-PDT on day 2. After completion of study, patients are followed up at 1 month, 2 months, 4 months, and then every 2 months for up to 12 months.

Conditions

Interventions

TypeNameDescription
OTHERLaboratory Biomarker AnalysisCorrelative studies
DRUGPhotodynamic TherapyUndergo image-guided I-PDT
DRUGPorfimer SodiumGiven IV

Timeline

Start date
2014-04-01
Primary completion
2016-10-13
Completion
2016-11-04
First posted
2014-02-21
Last updated
2017-10-11
Results posted
2017-08-28

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT02068157. Inclusion in this directory is not an endorsement.