NCT02067832

Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease

Applying Biomarkers to Long-term Effects in Child and Adolescent Cancer Treatment (ABLE Team) - Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 302 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Chronic graft-versus-host disease (cGVHD) can be hard to diagnose, difficult to manage and contributes significantly to morbidity and mortality in hematopoietic stem cell transplantation patients. The research will look into identifying and validating cGVHD biological indicators (=bio-markers) which will be evaluated whether they can predict a future development of the disease. The study hypothesis is that a number of previously reported cGVHD bio-markers, known to be present at the time of cGVHD diagnosis, will also be present at earlier time points, before cGVHD develops. Following validation, the bio-markers will be beneficial for finding those patients who are in higher risk to develop cGVHD. By identifying the higher-risk group, which is more likely to develop cGVHD, a pre-emptive therapy might be applied in order to prevent or reduce the prevalence of the disease.

Conditions

• Chronic Graft vs Host Disease

Timeline

• Start date: 2013-11-01
• Primary completion: 2024-12-01
• Completion: 2025-12-01
• First posted: 2014-02-20
• Last updated: 2023-12-05

Locations

25 sites across 3 countries: United States, Austria, Canada