NCT02066727

Lidocaine Combined Dexmedetomidine for Obturator Nerve Block

Effects of Dexmedetomidine as an Adjuvant on the Median Effective Concentration of Lidocaine for Obturator Nerve Block - A Perspective, Randomized，Blind Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Guolin Wang · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Hypothesis: Dexmedetomidine as an adjuvant of lidocaine can decrease the median effective concentration(EC50) of lidocaine for obturator nerve block during transurethral resection of bladder tumor

Detailed description

A selective obturator nerve block(ONB) is an effective alternative to suppress the obturator nerve reflex which is defined as a sudden, violent adductor muscle spasm when the obturator nerve is stimulated directly by the electronic resector during transurethral resection of the tumor on the lateral bladder wall. Studies showed Dexmedetomidine as an adjuvant to local anesthetic prolongs peripheral nerve block duration without any nerve toxicity. In the following randomized, non-crossover study, the investigators test if Dexmedetomidine as an adjuvant can decrease the median effective concentration(EC50) of lidocaine for obturator nerve block during transurethral resection of bladder tumor.

Conditions

• Nerve Block

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Dexmedetomidine is administrated as an adjuvant of lidocaine at a dose of 1.0 μg/ kg.
DRUG	Normal Saline	Normal Saline is administrated as an adjuvant of lidocaine.

Timeline

• Start date: 2014-02-01
• Primary completion: 2014-04-01
• Completion: 2014-05-01
• First posted: 2014-02-19
• Last updated: 2014-12-22
• Results posted: 2014-12-22

Locations

1 site across 1 country: China