NCT02062008

Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 2 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to understand how simultaneous PET/MR acquisition can provide novel qualitative and quantitative biomarkers to guide clinical intervention and predict prognosis of patients with cardiovascular disease.

Detailed description

* To compare regional myocardial uptake of FDG on images obtained on a standard PET camera with the new PET/MR camera, in patients with coronary artery disease. * To compare viability maps obtained with cardiac MR images and FDG-PET for delineation of myocardial infarct core and border zone, in patients with coronary artery disease. * To correlate MRI myocardial strain with relative myocardial FDG uptake in patients with a previous myocardial infarction. * To interrogate if simultaneous acquisition of cardiac PET and viability cardiac MR differ from acquisitions obtained independently, with special focus on attenuation correction methods * To combined MRI scar map with FDG-PET uptake in patients with cardiac sarcoidosis and myocarditis. * To correlate morphologic characteristics of atherosclerotic disease in the thoracic and abdominal aorta with FDG uptake and ferumoxytol enhancement, as a marker of inflammation. * To evaluate cardiac strain and myocardial scar burden in obese patients with and without diabetes.

Conditions

• Cardiac Disease

Interventions

Type	Name	Description
DEVICE	PET-MRI	PET-MRI with intravenous Gadolinium and FDG. The entire study will take approximately one hour.

Timeline

• Start date: 2016-12-01
• Primary completion: 2018-02-10
• Completion: 2018-02-10
• First posted: 2014-02-13
• Last updated: 2021-06-16
• Results posted: 2021-06-16

Locations

1 site across 1 country: United States